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Showing results 1 to 30 of 31

Issue DateTitleAuthor(s)
2016-01-14A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper MutantsYoon, Hojong; Kwak, Yeonui; Choi, Seunghye; Cho, Hanna; Kim, Nam Doo; Sim, Taebo
2015-03-19A Small Molecule Inhibitor of ATPase Activity of HSP70 Induces Apoptosis and Has Antitumor ActivitiesKo, Sung-Kyun; Kim, Jiyeon; Na, Deuk Chae; Park, Sookil; Park, Seong-Hyun; Hyun, Ji Young; Baek, Kyung-Hwa; Kim, Nam Doo; Kim, Nak-Kyoon; Park, Young Nyun; Song, Kiwon; Shin, Injae
2016-12Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung CancerBahcall, Magda; Sim, Taebo; Paweletz, Cloud P.; Patel, Jyoti D.; Alden, Ryan S.; Kuang, Yanan; Sacher, Adrian G.; Kim, Nam Doo; Lydon, Christine A.; Awad, Mark M.; Jaklitsch, Michael T.; Sholl, Lynette M.; Jaenne, Pasi A.; Oxnard, Geoffrey R.
2016-01Antitumor effects and molecular mechanisms of ponatinib on endometrial cancer cells harboring activating FGFR2 mutationsKim, Do-Hee; Kwak, Yeonui; Kim, Nam Doo; Sim, Taebo
2017-09-15Characterization of a highly selective inhibitor of the Aurora kinasesFerguson, Fleur M.; Doctor, Zainab M.; Chaikuad, Apirat; Sim, Taebo; Kim, Nam Doo; Knapp, Stefan; Gray, Nathanael S.
2014-08Daurinol, a catalytic inhibitor of topoisomerase II alpha, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phaseKang, Kyungsu; Nho, Chu Won; Kim, Nam Doo; Song, Dae-Geun; Park, Young Gyun; Kim, Minkyun; Pan, Cheol-Ho; Shin, Dongyun; Oh, Seung Hyun; Oh, Ho-Suk
2009-01-15Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitorsZhang, Yong; Jung, Seo Yoon; Jin, Changbae; Kim, Nam Doo; Gong, Ping; Lee, Yong Sup
2008-01-01Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitorsNam, Dong Hyuk; Lee, Kwang Seob; Kim, Sang Hoon; Kim, Sung Min; Jung, Seo Yun; Chung, Sung Hyun; Kim, Hyoung Ja; Kim, Nam Doo; Jin, Changbae; Lee, Yong Sup
2016-08Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in VivoSundberg, Thomas B.; Liang, Yanke; Wu, Huixian; Choi, Hwan Geun; Kim, Nam Doo; Sim, Taebo; Johannessen, Liv; Petrone, Adam; Khor, Bernard; Graham, Daniel B.; Latorre, Isabel J.; Phillips, Andrew J.; Schreiber, Stuart L.; Perez, Jose; Shamji, Alykhan F.; Gray, Nathanael S.; Xavier, Ramnik J.
2015-08-16Discovery of a potent, selective inhibitor of RET kinase including the V804L/V804M gatekeeper mutantsYoon, Hojong; Kwak, Yeonui; Sim, Taebo; Kim, Nam Doo; Cho, Kyung Seon; Choi, Seunghye
2020-06Discovery of a selective inhibitor of doublecortin like kinase 1Ferguson, Fleur M.; Nabet, Behnam; Raghavan, Srivatsan; Liu, Yan; Leggett, Alan L.; Kuljanin, Miljan; Kalekar, Radha L.; Yang, Annan; He, Shuning; Wang, Jinhua; Ng, Raymond W. S.; Sulahian, Rita; Li, Lianbo; Poulin, Emily J.; Huang, Ling; Koren, Jost; Dieguez-Martinez, Nora; Espinosa, Sergio; Zeng, Zhiyang; Corona, Cesear R.; Vastall, James D.; Ohi, Ryoma; Sim, Tae Bo; Kim, Nam Doo; Harshbarger, Wayne; Lizcano, Jose M.; Robers, Matthew B.; Muthaswamy, Senthil; Lin, Charles Y.; Look, A. Thomas; Haigis, Kevin M.; Mancias, Joseph D.; Wolpin, Brian M.; Aguirre, Andrew J.; Hahn, William C.; Westover, Kenneth D.; Gray, Nathanael S.
2016-10Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-delta/gamma InhibitorsFerguson, Fleur M.; Ni, Jing; Zhang, Tinghu; Tesar, Bethany; Sim, Taebo; Kim, Nam Doo; Deng, Xianming; Brown, Jennifer R.; Zhao, Jean J.; Gray, Nathanael S.
2019-06Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family SpecificityFerguson, Fleur M.; Doctor, Zainab M.; Ficarro, Scott B.; Browne, Christopher M.; Marto, Jarrod A.; Johnson, Jared L.; Yaron, Tomer M.; Cantley, Lewis C.; Kim, Nam Doo; Sim, Taebo; Berberich, Matthew J.; Kalocsay, Marian; Sorger, Peter K.; Gray, Nathanael S.
2018-09-27First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid LeukemiaCho, Hanna; Shin, Injae; Ju, Eunhye; Choi, Seunghye; Hur, Wooyoung; Kim, Haelee; Hong, Eunmi; Kim, Nam Doo; Choi, Hwan Geun; Gray, Nathanael S.; Sim, Taebo
2017-01-05Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxa mide as a specific RET kinase inhibitorYoon, Hojong; Shin, Injae; Nam, Yunju; Kim, Nam Doo; Lee, Kyung-Bok; Sim, Taebo
2019-10-24Identification of a Unique Resorcylic Acid Lactone Derivative That Targets Both Lymphangiogenesis and AngiogenesisHan, Youngsun; Sengupta, Sandip; Lee, Byung Joo; Cho, Hanna; Kim, Jiknyeo; Choi, Hwan Geun; Dash, Uttam; Kim, Jin Hyoung; Kim, Nam Doo; Kim, Jeong Hun; Sim, Taebo
2013-07-26Identification of methyl violet 2B as a novel blocker of focal adhesion kinase signaling pathway in cancer cellsKim, Hwan; Kim, Nam Doo; Lee, Jiyeon; Han, Gyoonhee; Sim, Taebo
2019-09-26Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) InhibitorsCho, Hanna; Shin, Injae; Cho, Kyungseon; Yoon, Hojong; Yoo, Eun Kyung; Kim, Mi-Jin; Park, Sungmi; Lee, In-Kyu; Kim, Nam Doo; Sim, Taebo
2022-04Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug ResistanceRyu, SeongShick; Nam, Yunju; Kim, Namkyoung; Shin, Injae; Jeon, Eunhye; Kim, Younghoon; Kim, Nam Doo; Sim, Taebo
2017-04Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasionSong, Chiman; Bae, Yeonju; Jun, JinJoo; Lee, Hyomin; Kim, Nam Doo; Lee, Kyung-Bok; Hur, Wooyoung; Park, Jae-Yong; Sim, Taebo
2017-02-23Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277Cho, Hanna; Sengupta, Sandip; Jeon, Sean S. H.; Hur, Wooyoung; Choi, Hwan Geun; Seo, Hong-Seog; Lee, Byung Joo; Kim, Jeong Hun; Chung, Minhwan; Jeon, Noo Li; Kim, Nam Doo; Sim, Taebo
2023-01Identification of Thiazolo[5,4-b]pyridine Derivatives as c-KIT Inhibitors for Overcoming Imatinib ResistanceNam, Yunju; Kim, Chan; Han, Junghee; Ryu Seong-Shick; Cho, Hanna; Song, Chiman; Kim, Nam Doo; Kim, Namkyoung; Sim, Taebo
2021-08Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3Cho, Hanna; Shin, Injae; Yoon, Hojong; Jeon, Eunhye; Lee, Jiwon; Kim, Younghoon; Ryu, Seong Shick; Song, Chiman; Kwon, Nam Hoon; Moon, Youngji; Kim, Sunghoon; Kim, Nam Doo; Choi, Hwan Geun; Sim, Tae Bo
2015-04In vitro metabolism of an estrogen-related receptor gamma modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450sJoo, Jeongmin; Wu, Zhexue; Lee, Boram; Shon, Jong Cheol; Lee, Taeho; Lee, In-Kyu; Sim, Taebo; Kim, Kyung-Hee; Kim, Nam Doo; Kim, Seong Heon; Liu, Kwang-Hyeon
2019-06Leveraging Compound Promiscuity to Identify Targetable Cysteines within the KinomeRao, Suman; Gurbani, Deepak; Du, Guangyan; Everley, Robert A.; Browne, Christopher M.; Chaikuad, Apirat; Tan, Li; Schroeder, Martin; Gondi, Sudershan; Ficarro, Scott B.; Sim, Taebo; Kim, Nam Doo; Berberich, Matthew J.; Knapp, Stefan; Marto, Jarrod A.; Westover, Kenneth D.; Sorger, Peter K.; Gray, Nathanael S.
2022-02Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1Ryu, SeongShick; Park, Jung-Eun; Ham, Young Jin; Lim, Daniel C.; Kwiatkowski, Nicholas P.; Kim, Do-Hee; Bhunia, Debabrata; Kim, Nam Doo; Yaffe, Michael B.; Son, Woolim; Kim, Namkyoung; Choi, Tae-Ik; Swain, Puspanjali; Kim, Cheol-Hee; Lee, Jin-Young; Gray, Nathanael S.; Lee, Kyung S.; Sim, Tae Bo
2012-02-18Rhodium-catalyzed reductive cyclization of 1,6-enynes and stereoselective synthesis of the putative structure of lucentamycin A and its stereoisomersHam, Young Jin; Yu, Hana; Kim, Nam Doo; Hah, Jung-Mi; Selim, Khalid B.; Choi, Hwan Geun; Sim, Taebo
2018-09Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and BromodomainsWang, Jinhua; Erazo, Tatiana; Ferguson, Fleur M.; Buckley, Dennis L.; Gomez, Nestor; Munoz-Guardiola, Pau; Dieguez-Martinez, Nora; Deng, Xianming; Hao, Mingfeng; Massefski, Walter; Fedorov, Oleg; Offei-Addo, Nana Kwaku; Park, Paul M.; Dai, Lingling; DiBona, Amy; Becht, Kelly; Kim, Nam Doo; McKeown, Michael R.; Roberts, Justin M.; Zhang, Jinwei; Sim, Taebo; Alessi, Dario R.; Bradner, James E.; Lizcano, Jose M.; Blacklow, Stephen C.; Qi, Jun; Xu, Xiang; Gray, Nathanael S.
2019-08Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14Ferguson, Fleur M.; Doctor, Zainab M.; Ficarro, Scott B.; Marto, Jarrod A.; Kim, Nam Doo; Sim, Taebo; Gray, Nathanael S.
2014-07-30Targeting transcription regulation in cancer with a covalent CDK7 inhibitorKwiatkowski, Nicholas; Zhang, Tinghu; Rahl, Peter B.; Abraham, Brian J.; Reddy, Jessica; Ficarro, Scott B.; Dastur, Anahita; Amzallag, Arnaud; Ramaswamy, Sridhar; Tesar, Bethany; Jenkins, Catherine E.; Hannett, Nancy M.; McMillin, Douglas; Sanda, Takaomi; Sim, Taebo; Kim, Nam Doo; Look, Thomas; Mitsiades, Constantine S.; Weng, Andrew P.; Brown, Jennifer R.; Benes, Cyril H.; Marto, Jarrod A.; Young, Richard A.; Gray, Nathanael S.
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