Browsing by Author Nathanael S. Gray

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Showing results 1 to 30 of 38

Issue DateTitleAuthor(s)
2014-11A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding RegionJamie A. Moroco; Matthew P. Baumgartner; Heather L. Rust, et al
2010-05A Small-Molecule Inducer of the Antioxidant Response Element허우영; Zheng Sun; Tao Jiang, et al
2010-03A Structure-Guided Approach to Creating Covalent FGFR InhibitorsWenjun Zhou; 허우영; Ultan McDermott, et al
2010-08A Type-II Kinase Inhibitor Capable of Inhibiting the T315I “Gatekeeper” Mutant of Bcr-Abl최환근; Pingda Ren; Francisco Adrian, et al
2010-07Broad spectrum alkynyl inhibitors of T315I Bcr-Abl임상민; Xianming Deng; Jianming Zhang, et al
2013-04Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATRQingsong Liu; Chunxiao Xu; Sivapriya Kirubakaran, et al
2008-07Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase허우영; Anastasia Velentza; Sungjoon Kim, et al
2012-09Development of ATP-Competitive mTOR Inhibitors허우영; Qingsong Liu; Seong A. Kang, et al
2014-11Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitorsLi Tan; Jun Wang; Junko Tanizaki, et al
2015-08Development of Small Molecules Targeting the Pseudokinase Her3심태보; 임상민; Ting Xie, et al
2012-08Development of ‘DFG-out’ inhibitors of gatekeeper mutant kinases최환근; Jianming Zhang; Ellen Weisberg, et al
2011-05Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stabilityQingsong Liu; Jinhua Wang; Seong A. Kang, et al
2010-09Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of CancerQingsong Liu; Jae Won Chang; Jinhua Wang, et al
2011-02Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)-phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of CancerQingsong Liu; Jinhua Wang; Seong A. Kang, et al
2013-04Discovery of a Selective Irreversible BMX Inhibitor for Prostate CancerFeiyang Liu; Xin Zhang; Ellen Weisberg, et al
2015-12Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance MutationJohn M. Hatcher; Magda Bahcall; Hwan Geun Choi, et al
2012-01Discovery of Potent and Selective Covalent Inhibitors of JNKTinghu Zhang; Francisco Inesta-Vaquera; Mario Niepel, et al
2009-12Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitorsGuobao Zhang; Pingda Ren; Nathanael S. Gray, et al
2015-01Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)Li Tan; Tyzoon Nomanbhoy; Deepak Gurbani, et al
2010-10Expanding the Diversity of Allosteric Bcr-Abl InhibitorsXianming Deng; Barun Okram; Qiang Ding, et al
1998-07Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitorsNathanael S. Gray; Lisa Wodicka; Andy-Mark W. H. Thunnissen, et al
2015-05Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approachAtsushi Nonami; Martin Sattler; Ellen Weisberg, et al
2014-06In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C임상민; John C. Hunter; Deepak Gurbani, et al
2012-03Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding KineticsQingsong Liu; Sivapriya Kirubakaran; 허우영, et al
2012-05Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy임상민; Zijuan Zhang; Nicholas Kwiatkowski, et al
2009-10N-Myristoylated c-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum upon Binding to an Allosteric InhibitorYongmun Choi; Markus A. Seeliger; Shoghag B. Panjarian, et al
2014-10Pharmacological targeting of the pseudokinase Her3심태보; 임상민; Ting Xie, et al
2014-12Pharmacological targeting of the pseudokinase Her3Ting Xie; Sang Min Lim; Kenneth D. Westover, et al
2012-04Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiaeQingsong Liu; Tao Ren; Tara Fresques, et al
2012-04Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine KinaseSabine Hellwig; Chandra V. Miduturu; Shigeru Kanda, et al