The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons.

Title
The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons.
Authors
이창준황은미권재Go Eun HaJaekwang LeeHankyul KwakKiyeong SongSoon-Young JungJoohyeon HongGyeong-Eon ChangHee-Sup ShinEunji Cheong
Issue Date
2016-12
Publisher
Nature Communications
Citation
VOL 7-13791-13
Abstract
Neuronal fi ring patterns, which are crucial for determining the nature of encoded information, have been widely studied; however, the molecular identity and cellular mechanisms of spike-frequency adaptation are still not fully understood. Here we show that spike-frequency adaptation in thalamocortical (TC) neurons is mediated by the Ca2þ-activated Cl channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in TC neurons results in signifi cantly reduced spike-frequency adaptation along with increased tonic spiking. Moreover, thalamusspecifi c knockdown of ANO2 increases visceral pain responses. These results indicate that ANO2 contributes to reductions in spike generation in highly activated TC neurons and thereby restricts persistent information transmission.
URI
http://pubs.kist.re.kr/handle/123456789/64618
ISSN
2041-1723
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KIST Publication > Article
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