Inhibitory effect of the Larix sibirica and its various flavonoids on the IgE-stimulated mast cell activation and anaphylaxis

Title
Inhibitory effect of the Larix sibirica and its various flavonoids on the IgE-stimulated mast cell activation and anaphylaxis
Authors
노주원김명석김선영임수지반츠라크치아흐마드 란디
Keywords
Larix sibirica; RBL-2H3; flavonoids; anaphylaxis
Issue Date
2016-12
Publisher
Journal of Functional Foods
Citation
VOL 27-644
Abstract
Larix sibirica (Siberian larch) is a deciduous tree native to Russia, Mongolia, and China and has been reported to possess anti-viral, anti-oxidant, and neuroprotective properties. In this study, we assessed the anti-allergic effects of an L. sibirica extract (LSE) and its various flavonoids using an IgE-sensitized mast cell-like cell line, rat basophilic leukaemia (RBL)-2H3, and a passive anaphylaxis mouse model. In IgE-sensitized RBL-2H3 cells, LSE and several flavonoids reduced release and production of β-hexosaminidase, histamine, and inflammatory mediators (prostaglandin D2, leukotriene C4, interleukin-4, and tumour necrosis factor-α), reduced expression of cyclooxygenase-2 and 5-lipoxygenase, and suppressed activation of nuclear factor-κB. LSE and several flavonoids reduced phosphorylation of downstream signalling molecules, such as Syk, protein kinase Cµ , phospholipase Cγ, and mitogen-activated protein kinases. Oral administration of LSE inhibited mast cell-dependent passive cutaneous anaphylactic reactions. These results suggest that LSE is a beneficial candidate for the prevention and treatment of allergic disorders.
URI
http://pubs.kist.re.kr/handle/123456789/64705
ISSN
1756-4646
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KIST Publication > Article
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