Reconfigurable and Portable Highly Sensitive Biosensor Platform for ISFET and Enzyme-Based Sensors

Title
Reconfigurable and Portable Highly Sensitive Biosensor Platform for ISFET and Enzyme-Based Sensors
Authors
이현정이기영Ikho LeeSeung-Woo LeeChanoh ParkDonghoon KimJeong-Soo LeeByungsub Kim
Keywords
biosensor platform; Si NW ISFET; enzyme-based catechol sensor; amperometry; cyclic voltammetry; linear sweep voltammetry
Issue Date
2016-06
Publisher
IEEE sensors journal
Citation
VOL 16, NO 11-4451
Abstract
This paper presents a portable low-cost biosensor platform for ion-sensitive field-effect transistor (ISFET) and enzyme-based sensors. To meet various demands of diagnosis, our portable platform is designed to perform cyclic voltammetry, amperometry, and linear sweep voltammetry for enzyme-based sensor and ISFET sensor. For compatibility with various sensors which require various electrical driving schemes, our system can be easily reconfigured by simple switches. In addition, with disposable printed-circuit-board packages, sensors can be easily replaced. Our platform was tested with various sensors in various measurement methods. In cyclic voltammetry test with a model analyte K3Fe(CN)(6), a graph provided by our system has 4.79% relative error at a current peak compared with the data acquired by a 18 times more expensive commercial system. In cyclic voltammetry and amperometry tests with the laccase enzyme-based sensors, our system achieved sensitivities of 341 and 500 mu A/mM/cm(2), respectively. By running a sensitive SiNW ISFET on our platform in linear sweep voltammetry, we could build a low-cost portable pH sensor system.
URI
http://pubs.kist.re.kr/handle/123456789/64741
ISSN
1530-437X
Appears in Collections:
KIST Publication > Article
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