The effects of nanotopography and coculture systems to promote angiogenesis for wound repair

Title
The effects of nanotopography and coculture systems to promote angiogenesis for wound repair
Authors
김수현정영미김태희
Issue Date
2016-11
Publisher
NANOMEDICINE
Citation
VOL 11, NO 22-3007
Abstract
Insufficient angiogenesis in severe wounds delays wound repair because of a lack of blood supply to the wound site. Therefore, pro-angiogenic therapeutics may enhance wound repair. Many studies have investigated various physical and biochemical cues to improve angiogenesis, such as biocompatible materials, surface modifications, angiogenic factors and coculture systems using various cell types. However, the present capability to mimic the micro- and nanostructure of the natural microenvironment, particularly its porous, fibrous features, is limited. Nanotopography may represent a promising tool to overcome these limitations. Here, we discuss various approaches to the use of nanotopography to enhance angiogenesis and consider the combination of coculture systems with nanotopography to mimic the native environment for promotion of angiogenesis in wound healing and repair.
URI
http://pubs.kist.re.kr/handle/123456789/64745
ISSN
1743-5889
Appears in Collections:
KIST Publication > Article
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