Synthesis and activity as a glycosidase inhibitor of 2,8-dihydroxyindolizidines

Title
Synthesis and activity as a glycosidase inhibitor of 2,8-dihydroxyindolizidines
Authors
나호성최재혁유재훈신계정유경호김동진박상우
Keywords
Indolizidine Alkaloids; 2,8-Dihydroxyindolizidines; Glycosidase Inhibitor; Four Diastereomers
Issue Date
1998-01
Publisher
Heterocycles
Citation
VOL 48, NO 11, 2365-2378
Abstract
The synthesis and enzyme assay of 2,8-dihydroxyindolizidines (5) were described. Four diastereomers of these were prepared from trans-4-hydroxy-L-proline (6) which is commercially available amino acid. Among synthetic compounds 5a1 and 5b2 showed medium potent inhibition to α-amyloglycosidase, while 5a2 displayed medium activity to α-glucosidase
URI
http://pubs.kist.re.kr/handle/201004/11109
ISSN
0385-5414
Appears in Collections:
KIST Publication > Article
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