MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications

Authors
Artan, MuratSohn, JooyeonLee, CheoljuPark, Seung-YeolLee, Seung-Jae, V
Issue Date
2022-05
Publisher
Landes Bioscience
Citation
Autophagy, v.18, no.5, pp.1208 - 1210
Abstract
The Golgi apparatus regulates the process of modification and subcellular localization of macromolecules, including proteins and lipids. Aberrant protein sorting caused by defects in the Golgi leads to various diseases in mammals. However, the role of the Golgi apparatus in organismal longevity remained largely unknown. By employing a quantitative proteomic approach, we demonstrated that MON-2, an evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking, promotes longevity via upregulating macroautophagy/autophagy in C. elegans. Our data using cultured mammalian cells indicate that MON-2 translocates from the Golgi to the endosome under starvation conditions, subsequently increasing autophagic flux by binding LGG-1/GABARAPL2. Thus, Golgi-to-endosome trafficking appears to be an evolutionarily conserved process for the upregulation of autophagy, which contributes to organismal longevity.
Keywords
Aging; autophagy; C. elegans; Golgi; LGG-1/GABARAPL2; lifespan; MON-2/MON2; proteomics
ISSN
1554-8627
URI
https://pubs.kist.re.kr/handle/201004/115251
DOI
10.1080/15548627.2022.2039523
Appears in Collections:
KIST Article > 2022
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