Thermosensitive and cell-adhesive pluronic hydrogels for human adipose-derived stem cells

Authors
Park, KwideokJung, Hong HeeSon, Jun SikRhie, Jong-WonPark, Ki DongAhn, Kwang-DukHan, Dong Keun
Issue Date
2007
Publisher
TRANS TECH PUBLICATIONS LTD
Citation
7th Asian Symposium on Biomedical Materials (ASBM7), v.342-343, pp.301 - +
Abstract
Pluronic F127 has received increasing attention over many years as drug delivery systems, biomaterials, and hydrogels for tissue engineering. In this study, we synthesized temperature-sensitive and cell-adhesive triblock F127 copolymers, in which Arg-Gly-Asp (RGD) peptide ligand was grafted to Pluronic F127-4-methacryloxyethyl trimellitic anhydride (4-META) to obtain F127-META-RGD. The chemical structures of the F127-META-RGD block copolymers were confirmed by FTIR, H-1 and C-13 NMR, and GPC. The resultant F127-META-RGD showed very similar thermosensitive behaviors to F127 and 17127-META. The critical micelle temperature (CMT) of the F127 copolymers decreased in the order of F127 < F127-META < F127-META-RGD, whereas the particle size followed an opposite trend. Interactions between the F127 copolymers and adipose-clerived stein cells (ASC) were evaluated in terms of cell adhesion and proliferation on the hydrogel. These thermosensitive RGD-grafted Pluronic hydrogels that display the enhanced cell adhesiveness, are expected to be useful as a functional injectable scaffold for tissue engineering.
ISSN
1013-9826
URI
https://pubs.kist.re.kr/handle/201004/116411
DOI
10.4028/www.scientific.net/KEM.342-343.301
Appears in Collections:
KIST Conference Paper > 2007
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