Extracellular Vesicles as Potential Theranostic Platforms for Skin Diseases and Aging

Authors
Kim, HyosukLee, Jong WonHan, GeonheeKim, KwangmeyungYang, YoosooKim, Sun Hwa
Issue Date
2021-05
Publisher
MDPI
Citation
PHARMACEUTICS, v.13, no.5
Abstract
Extracellular vesicles (EVs), naturally secreted by cells, act as mediators for communication between cells. They are transported to the recipient cells along with cargoes such as nucleic acids, proteins, and lipids that reflect the changes occurring within the parent cells. Thus, EVs have been recognized as potential theranostic agents for diagnosis, treatment, and prognosis. In particular, the evidence accumulated to date suggests an important role of EVs in the initiation and progression of skin aging and various skin diseases, including psoriasis, systemic lupus erythematosus, vitiligo, and chronic wounds. This review highlights recent research that investigates the role of EVs and their potential as biomarkers and therapeutic agents for skin diseases and aging.
Keywords
SYSTEMIC-LUPUS-ERYTHEMATOSUS; MESENCHYMAL STEM-CELLS; CELLULAR SENESCENCE; STEM/STROMAL CELLS; EXOSOMAL MICRORNAS; DERMAL FIBROBLASTS; OXIDATIVE STRESS; MOUSE MODEL; DELIVERY; PROMOTE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; MESENCHYMAL STEM-CELLS; CELLULAR SENESCENCE; STEM/STROMAL CELLS; EXOSOMAL MICRORNAS; DERMAL FIBROBLASTS; OXIDATIVE STRESS; MOUSE MODEL; DELIVERY; PROMOTE; skin disease; skin aging; extracellular vesicles; biomarker; therapy
ISSN
1999-4923
URI
https://pubs.kist.re.kr/handle/201004/117027
DOI
10.3390/pharmaceutics13050760
Appears in Collections:
KIST Article > 2021
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