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dc.contributor.authorHwang, Jee Won-
dc.contributor.authorCho, Yena-
dc.contributor.authorBae, Gyu-Un-
dc.contributor.authorKim, Su-Nam-
dc.contributor.authorKim, Yong Kee-
dc.date.accessioned2024-01-19T14:34:25Z-
dc.date.available2024-01-19T14:34:25Z-
dc.date.created2021-10-21-
dc.date.issued2021-05-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/117036-
dc.description.abstractCancer therapy: Exploring possible enzyme targets Understanding the roles, regulation and downstream targets of a family of enzymes involved in cancer development could improve future therapies. Yong Kee Kim at Sookmyung Women's University, Seoul, South Korea, and co-workers reviewed current knowledge of protein arginine methyltransferases (PRMTs), their influence on cell cycle regulation and DNA damage responses in cancer, and their potential as anti-cancer targets. PRMTs act as catalysts in modification of the amino acid arginine. This process is critical to healthy cellular function, and its disruption is linked to cancer development. The overexpression of certain PRMTs is a driving factor in cancer tumor growth, metastasis and poor prognosis. PRMT inhibitors are showing promise in clinical trials for B-cell lymphoma and various solid tumors. Combined therapies targeting more than one PRMT could prove valuable. Protein methylation, a post-translational modification (PTM), is observed in a wide variety of cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic research, the importance of protein methylation has been highlighted. The methylation of histone proteins that contributes to the epigenetic histone code is not only dynamic but is also finely controlled by histone methyltransferases and demethylases, which are essential for the transcriptional regulation of genes. In addition, many nonhistone proteins are methylated, and these modifications govern a variety of cellular functions, including RNA processing, translation, signal transduction, DNA damage response, and the cell cycle. Recently, the importance of protein arginine methylation, especially in cell cycle regulation and DNA repair processes, has been noted. Since the dysregulation of protein arginine methylation is closely associated with cancer development, protein arginine methyltransferases (PRMTs) have garnered significant interest as novel targets for anticancer drug development. Indeed, several PRMT inhibitors are in phase 1/2 clinical trials. In this review, we discuss the biological functions of PRMTs in cancer and the current development status of PRMT inhibitors in cancer therapy.-
dc.languageEnglish-
dc.publisher생화학분자생물학회-
dc.titleProtein arginine methyltransferases: promising targets for cancer therapy-
dc.typeArticle-
dc.identifier.doi10.1038/s12276-021-00613-y-
dc.description.journalClass1-
dc.identifier.bibliographicCitationExperimental & Molecular Medicine, v.53, no.5, pp.788 - 808-
dc.citation.titleExperimental & Molecular Medicine-
dc.citation.volume53-
dc.citation.number5-
dc.citation.startPage788-
dc.citation.endPage808-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART002717935-
dc.identifier.wosid000651673500001-
dc.identifier.scopusid2-s2.0-85106242160-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.type.docTypeReview-
dc.subject.keywordPlusMESSENGER-RNA-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusHISTONE H3-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusCELL-GROWTH-
dc.subject.keywordPlusSM PROTEINS-
dc.subject.keywordPlusTRANSCRIPTIONAL REPRESSION-
dc.subject.keywordPlusHEPATOCELLULAR-CARCINOMA-
dc.subject.keywordPlusMESENCHYMAL-TRANSITION-
dc.subject.keywordPlusALLOSTERIC INHIBITOR-
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