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dc.contributor.authorKim, E.-
dc.contributor.authorKim, H.J.-
dc.contributor.authorOh, H.-N.-
dc.contributor.authorKwak, A.-W.-
dc.contributor.authorKim, S.-N.-
dc.contributor.authorKang, B.Y.-
dc.contributor.authorCho, S.-S.-
dc.contributor.authorShim, J.-H.-
dc.contributor.authorYoon, G.-
dc.date.accessioned2024-01-19T20:33:53Z-
dc.date.available2024-01-19T20:33:53Z-
dc.date.created2021-08-31-
dc.date.issued2019-03-
dc.identifier.issn1226-3907-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/120318-
dc.description.abstractBioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC50 values of 9.15 and 13.95 ？M, respectively. ？ 2019, Korean Society of Pharmacognosy. All rights reserved.-
dc.languageEnglish-
dc.publisherKorean Society of Pharmacognosy-
dc.subject2e,4e,8z,10e n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide-
dc.subject2e,4e,8z,10z n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide-
dc.subjectasarinin-
dc.subjectAsarum sieboldii extract-
dc.subjectfluorouracil-
dc.subjectmethylkakuol-
dc.subjectplant extract-
dc.subjectsesamin-
dc.subjectunclassified drug-
dc.subjectxanthoxylol-
dc.subjectantineoplastic activity-
dc.subjectArticle-
dc.subjectAsarum sieboldii-
dc.subjectbreast cancer-
dc.subjectcarbon nuclear magnetic resonance-
dc.subjectcell viability-
dc.subjectchemical structure-
dc.subjectcontrolled study-
dc.subjectcytotoxicity-
dc.subjectdrug synthesis-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjectIC50-
dc.subjectinfrared spectroscopy-
dc.subjectMCF-7 cell line-
dc.subjectMDA-MB-231 cell line-
dc.subjectmedicinal plant-
dc.subjectMTT assay-
dc.subjectproton nuclear magnetic resonance-
dc.titleCytotoxic constituents from the roots of asarum sieboldii in human breast cancer cells-
dc.typeArticle-
dc.identifier.doi10.20307/NPS.2019.25.1.72-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNatural Product Sciences, v.25, no.1, pp.72 - 75-
dc.citation.titleNatural Product Sciences-
dc.citation.volume25-
dc.citation.number1-
dc.citation.startPage72-
dc.citation.endPage75-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.scopusid2-s2.0-85071928113-
dc.type.docTypeArticle-
dc.subject.keywordPlus2e,4e,8z,10e n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide-
dc.subject.keywordPlus2e,4e,8z,10z n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide-
dc.subject.keywordPlusasarinin-
dc.subject.keywordPlusAsarum sieboldii extract-
dc.subject.keywordPlusfluorouracil-
dc.subject.keywordPlusmethylkakuol-
dc.subject.keywordPlusplant extract-
dc.subject.keywordPlussesamin-
dc.subject.keywordPlusunclassified drug-
dc.subject.keywordPlusxanthoxylol-
dc.subject.keywordPlusantineoplastic activity-
dc.subject.keywordPlusArticle-
dc.subject.keywordPlusAsarum sieboldii-
dc.subject.keywordPlusbreast cancer-
dc.subject.keywordPluscarbon nuclear magnetic resonance-
dc.subject.keywordPluscell viability-
dc.subject.keywordPluschemical structure-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPluscytotoxicity-
dc.subject.keywordPlusdrug synthesis-
dc.subject.keywordPlushuman-
dc.subject.keywordPlushuman cell-
dc.subject.keywordPlusIC50-
dc.subject.keywordPlusinfrared spectroscopy-
dc.subject.keywordPlusMCF-7 cell line-
dc.subject.keywordPlusMDA-MB-231 cell line-
dc.subject.keywordPlusmedicinal plant-
dc.subject.keywordPlusMTT assay-
dc.subject.keywordPlusproton nuclear magnetic resonance-
dc.subject.keywordAuthorAsarum sieboldii-
dc.subject.keywordAuthorBreast cancer-
dc.subject.keywordAuthorCytotoxicity-
dc.subject.keywordAuthorXanthoxylol-
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