Atroposelective Synthesis of PINAP via Dynamic Kinetic Asymmetric Transformation

Abstract

The atroposelective synthesis of PINAP ligands has been accomplished via a palladium-catalyzed C-P coupling process through dynamic kinetic asymmetric transformation. These catalytic conditions allow access to a wide variety of alkoxy- and benzyloxy-substituted PINAP ligands in high enantiomeric excess. The methods described in this communication afford valuable P,N ligands in good yields and high enantioselectivity using low catalyst loading.