Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box

Title
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box
Authors
김혜연조윤제
Keywords
tumour suppressor
Issue Date
1997-05
Publisher
Nature structural biology
Citation
VOL 4, NO 5, 390-395
Abstract
The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378−562) at 2.3 Å resolution. Domain A consists of nine -helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
URI
http://pubs.kist.re.kr/handle/201004/12055
ISSN
1072-8368
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE