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Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

Authors: Hien Bao Dieu Thai; Levi-Acobas, Fabienne; Yum, Soo-Young; Jang, Goo; Hollenstein, Marcel; Ahn, Dae-Ro

Issue Date: 2018-09-04

Publisher: ROYAL SOC CHEMISTRY

Citation: CHEMICAL COMMUNICATIONS, v.54, no.68, pp.9410 - 9413

Abstract: We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.

Keywords: IN-VITRO SELECTION; DNA NANOSTRUCTURES; ANTISENSE OLIGONUCLEOTIDES; DELIVERY; RNA; DEOXYRIBOZYMES; NANOCARRIERS; TOLERABILITY; STABILITY; ENZYMES; IN-VITRO SELECTION; DNA NANOSTRUCTURES; ANTISENSE OLIGONUCLEOTIDES; DELIVERY; RNA; DEOXYRIBOZYMES; NANOCARRIERS; TOLERABILITY; STABILITY; ENZYMES

ISSN: 1359-7345

URI: https://pubs.kist.re.kr/handle/201004/120931

DOI: 10.1039/c8cc05721d

Appears in Collections:: KIST Article > 2018

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