Cytotoxic effects of quinoxaline derivatives on human cancer cell lines

Title
Cytotoxic effects of quinoxaline derivatives on human cancer cell lines
Authors
유희원이윤실서명은김동진박상우
Keywords
6,7-modified-5,8-quinoxalinedione; heterocyclic quinoxaline derivatives; human gastric adenocarcinoma cell line
Issue Date
1998-01
Publisher
Archiv der Pharmazie
Citation
VOL 331, NO 10, 331-333
Abstract
The cytotoxicities of 6,7-modified-5,8-quinoxalinedione derivatives and heterocyclic quinoxaline derivatives containing nitrogen, sulfur, and oxygen on human lung adenocarcinoma cell (PC 14), human gastric adenocarcinoma cell (MKN 45), and human colon adenocarcinoma cell (colon 205) were examined in vitro using MTT assay. Pyrido[1,2-a]imidazo[4,5-g]quinoxaline-6,11-dione (10) was markedly cytotoxic against MKN 45 compared with adriamycin and cis-platin used as anticancer drugs. The IC50 value of compound 10 was 0.073 mM while those of adriamycin and cis-platin were 0.12 mM and 2.67 mM, respectively.
URI
http://pubs.kist.re.kr/handle/201004/12347
ISSN
0365-6233
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KIST Publication > Article
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