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dc.contributor.authorKim, Ji-Sun-
dc.contributor.authorCheon, Soyoung-
dc.contributor.authorKim, Seung Woo-
dc.contributor.authorKim, Boram-
dc.contributor.authorKim, Heejaung-
dc.contributor.authorPark, Ki Duk-
dc.contributor.authorKim, Sung-Min-
dc.date.accessioned2024-01-20T03:31:20Z-
dc.date.available2024-01-20T03:31:20Z-
dc.date.created2021-09-05-
dc.date.issued2016-09-16-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/123669-
dc.description.abstractNeuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system and is mediated by complement-dependent cytotoxicity (CDC) of NMO-specific immunoglobulin G (IgG) antibodies (NMO-IgG). Glycyrrhizic acid (GA) has numerous pharmacological effects including inhibition of the complement pathway. We aimed to study the influence of GA on NMO-IgG-induced CDC. NMO-IgG samples from 7 patients with NMO, together with human complement, induced CDC in an aquaporin 4 M23-overexpressing glial cell line, an in vitro NMO model. GA attenuated NMO-IgG-induced CDC in a dose-dependent manner. The mechanism of the GA-related CDC inhibition was sequentially dissected and found to involve inhibition of C1q binding to NMO-IgG. Consequently, GA attenuates NMO-IgG-induced CDC and may be a promising novel therapeutic agent against NMO. (C) 2016 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectCOMPLEMENT-DEPENDENT CYTOTOXICITY-
dc.subjectMULTIPLE-SCLEROSIS-
dc.subjectRETROSPECTIVE ANALYSIS-
dc.subjectDIAGNOSTIC-CRITERIA-
dc.subjectSPECTRUM DISORDERS-
dc.subjectWATER CHANNEL-
dc.subjectIN-VITRO-
dc.subjectMARKER-
dc.subjectTHERAPIES-
dc.subjectPROTEIN-
dc.titleGlycyrrhizic acid prevents astrocyte death by neuromyelitis optica-specific IgG via inhibition of C1q binding-
dc.typeArticle-
dc.identifier.doi10.1016/j.bbrc.2016.07.098-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.478, no.2, pp.553 - 558-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume478-
dc.citation.number2-
dc.citation.startPage553-
dc.citation.endPage558-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000383528600008-
dc.identifier.scopusid2-s2.0-84995680638-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.type.docTypeArticle-
dc.subject.keywordPlusCOMPLEMENT-DEPENDENT CYTOTOXICITY-
dc.subject.keywordPlusMULTIPLE-SCLEROSIS-
dc.subject.keywordPlusRETROSPECTIVE ANALYSIS-
dc.subject.keywordPlusDIAGNOSTIC-CRITERIA-
dc.subject.keywordPlusSPECTRUM DISORDERS-
dc.subject.keywordPlusWATER CHANNEL-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusMARKER-
dc.subject.keywordPlusTHERAPIES-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordAuthorGlycyrrhizic acid-
dc.subject.keywordAuthorNeuromyelitis optica-
dc.subject.keywordAuthorComplement dependent cytotoxicity-
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