DSpace at KISTKIST Article2012

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dc.contributor.authorHan, Younghue-
dc.contributor.authorHan, Minsoo-
dc.contributor.authorShin, Dongyun-
dc.contributor.authorSong, Chiman-
dc.contributor.authorHahn, Hoh-Gyu-
dc.date.accessioned2024-01-20T14:01:56Z-
dc.date.available2024-01-20T14:01:56Z-
dc.date.created2021-09-05-
dc.date.issued2012-09-27-
dc.identifier.issn0022-2623-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128859-
dc.description.abstractNovel azetidines based on the 3-aryl-3-oxypropylamine scaffold were designed, synthesized, and evaluated as TRIs. Reduction of 1 followed by Swern oxidation and then Grignard reaction gave 3. The alkylation of 3 provided the corresponding azetidine derivatives 6, of which the two most promising, 6bd and 6be, were selected from 86 prepared analogues based on their biological profiles. Compound 6be showed activity in vivo in FST at 10 mg/kg IV or 20-40 mg/kg PO.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectMONOAMINE TRANSPORTER INHIBITORS-
dc.subjectMAJOR DEPRESSIVE DISORDER-
dc.subjectCOMBINATION-
dc.subjectDISCOVERY-
dc.subjectBUPROPION-
dc.subjectEFFICACY-
dc.subjectDULOXETINE-
dc.subjectDRUGS-
dc.titleExploration of Novel 3-Substituted Azetidine Derivatives As Triple Reuptake Inhibitors-
dc.typeArticle-
dc.identifier.doi10.1021/jm3008294-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF MEDICINAL CHEMISTRY, v.55, no.18, pp.8188 - 8192-
dc.citation.titleJOURNAL OF MEDICINAL CHEMISTRY-
dc.citation.volume55-
dc.citation.number18-
dc.citation.startPage8188-
dc.citation.endPage8192-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000309153500022-
dc.identifier.scopusid2-s2.0-84866840102-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusMONOAMINE TRANSPORTER INHIBITORS-
dc.subject.keywordPlusMAJOR DEPRESSIVE DISORDER-
dc.subject.keywordPlusCOMBINATION-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlusBUPROPION-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusDULOXETINE-
dc.subject.keywordPlusDRUGS-
dc.subject.keywordAuthornovel pharmaceutical-
dc.subject.keywordAuthorazetidine-
dc.subject.keywordAuthorCNS-
dc.subject.keywordAuthorantidepression-
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