Full metadata record

DC Field Value Language
dc.contributor.authorKoo, Heebeom-
dc.contributor.authorMoon, Hyungwon-
dc.contributor.authorHan, Hyounkoo-
dc.contributor.authorNa, Jin Hee-
dc.contributor.authorHuh, Myung Sook-
dc.contributor.authorPark, Jae Hyung-
dc.contributor.authorWood, Se Joon-
dc.contributor.authorPark, Kyu Hyung-
dc.contributor.authorKwon, Ick Chan-
dc.contributor.authorKim, Kwangmeyung-
dc.contributor.authorKim, Hyuncheol-
dc.date.accessioned2024-01-20T15:04:02Z-
dc.date.available2024-01-20T15:04:02Z-
dc.date.created2021-09-04-
dc.date.issued2012-04-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/129407-
dc.description.abstractThe purpose of this study is to determine the correlation between the distribution of nanoparticles in the vitreous and retina and their surface properties after intravitreal injection. For this purpose, we synthesized seven kinds of nanoparticles through self-assembly of amphiphilic polymer conjugates in aqueous condition. They showed similar size but different surface properties. They were labeled with fluorescent dyes for efficient tracking. After intravitreal injection of these nanoparticles into a rodent eye, their time-dependent distribution in the vitreous and retina was determined in stacking tissue images by confocal microscopy. The results demonstrated that the surface property of nanoparticles is a key factor in determining their distribution in the vitreous and retina after intravitreal injection. In addition, immunohistochemistry and TEM images of retina tissues suggested the important mechanism related with Muffler cells for intravitreally administered nanoparticles to overcome the physical barrier of inner limiting membrane and to penetrate into the deeper retinal structures. Therefore, we expect that this study can provide valuable information for biomedical researchers to develop optimized nanoparticles as drug or gene carriers for retinal and optic nerve disorders such as glaucoma, age-related macular degeneration, and diabetic retinopathy. (C) 2012 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectGROWTH-FACTOR THERAPY-
dc.subjectDRUG-DELIVERY-
dc.subjectMACULAR DEGENERATION-
dc.subjectTARGETED DELIVERY-
dc.subjectGENE DELIVERY-
dc.subjectORGANIZATION-
dc.subjectCHITOSAN-
dc.subjectSYSTEM-
dc.subjectSIRNA-
dc.titleThe movement of self-assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection-
dc.typeArticle-
dc.identifier.doi10.1016/j.biomaterials.2012.01.030-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOMATERIALS, v.33, no.12, pp.3485 - 3493-
dc.citation.titleBIOMATERIALS-
dc.citation.volume33-
dc.citation.number12-
dc.citation.startPage3485-
dc.citation.endPage3493-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000301886300011-
dc.identifier.scopusid2-s2.0-84862782522-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeArticle-
dc.subject.keywordPlusGROWTH-FACTOR THERAPY-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusMACULAR DEGENERATION-
dc.subject.keywordPlusTARGETED DELIVERY-
dc.subject.keywordPlusGENE DELIVERY-
dc.subject.keywordPlusORGANIZATION-
dc.subject.keywordPlusCHITOSAN-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusSIRNA-
dc.subject.keywordAuthorOcular-
dc.subject.keywordAuthorIntravitreal-
dc.subject.keywordAuthorNanoparticle-
dc.subject.keywordAuthorDrug delivery-
dc.subject.keywordAuthorVitreous-
dc.subject.keywordAuthorRetina-
Appears in Collections:
KIST Article > 2012
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE