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dc.contributor.authorKim, Nam Hyun-
dc.contributor.authorKim, Su-Nam-
dc.contributor.authorOh, Joa Sub-
dc.contributor.authorLee, Seokjoon-
dc.contributor.authorKim, Yong Kee-
dc.date.accessioned2024-01-20T15:30:56Z-
dc.date.available2024-01-20T15:30:56Z-
dc.date.created2021-09-05-
dc.date.issued2012-02-24-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/129525-
dc.description.abstractIn this study, we investigate an anti-mitotic potential of the novel synthetic coumarin-based compound, 7-diethylamino-3(2'-benzoxazolyl)-coumarin, in 5-fluorouracil-resistant human gastric cancer cell line SNU-620-5FU and its parental cell SNU-620. It exerts the anti-proliferative effects with similar potencies against both cancer cells, which is mediated by destabilization of microtubules and subsequent mitotic arrest. Furthermore, this compound enhances caspase-dependent apoptotic cell death via decreased expression of anti-apoptotic genes. Taken together, our data strongly support anti-mitotic potential of 7-diethylamino-3(2'-benzoxazolyl)-coumarin against drug-resistant cancer cells which will prompt us to further develop as a novel microtubule inhibitor for drug-resistant cancer chemotherapy. (C) 2012 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectAURORA KINASES-
dc.subjectDRUGS-
dc.subjectAGENTS-
dc.subjectMICROTUBULES-
dc.subjectINHIBITORS-
dc.subjectTHERAPY-
dc.subjectTARGET-
dc.titleAnti-mitotic potential of 7-diethylamino-3(2 '-benzoxazolyl)-coumarin in 5-fluorouracil-resistant human gastric cancer cell line SNU620/5-FU-
dc.typeArticle-
dc.identifier.doi10.1016/j.bbrc.2012.01.049-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.418, no.4, pp.616 - 621-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume418-
dc.citation.number4-
dc.citation.startPage616-
dc.citation.endPage621-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000301332100006-
dc.identifier.scopusid2-s2.0-84862793621-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.type.docTypeArticle-
dc.subject.keywordPlusAURORA KINASES-
dc.subject.keywordPlusDRUGS-
dc.subject.keywordPlusAGENTS-
dc.subject.keywordPlusMICROTUBULES-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusTARGET-
dc.subject.keywordAuthor7-Diethylamino-3(2 &apos-
dc.subject.keywordAuthor-benzoxazolyl)-coumarin-
dc.subject.keywordAuthorMicrotubule-
dc.subject.keywordAuthorDrug resistance-
dc.subject.keywordAuthor5FU-
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