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dc.contributor.authorUllapu, Punna Reddy-
dc.contributor.authorKu, Su Jin-
dc.contributor.authorChoi, Yeon Hee-
dc.contributor.authorPark, Jiyeon-
dc.contributor.authorHan, So-Yeop-
dc.contributor.authorBaek, Du Jong-
dc.contributor.authorLee, Jaekyun-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorMin, Sun-Joon-
dc.contributor.authorCho, Yong Seo-
dc.date.accessioned2024-01-20T16:32:07Z-
dc.date.available2024-01-20T16:32:07Z-
dc.date.created2021-09-04-
dc.date.issued2011-08-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130071-
dc.description.abstractThe synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 211 exhibiting the most potent T-type calcium channel blocking activity with IC(50) value of 0.20 mu M, which is superior to that of mibefradil.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subjectCA2+ CHANNELS-
dc.subjectANTAGONISTS-
dc.subjectINHIBITION-
dc.subjectACID-
dc.titleSynthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2011.32.8.3063-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.32, no.8, pp.3063 - 3073-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume32-
dc.citation.number8-
dc.citation.startPage3063-
dc.citation.endPage3073-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001576729-
dc.identifier.wosid000297383700048-
dc.identifier.scopusid2-s2.0-84866768417-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordPlusANTAGONISTS-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusACID-
dc.subject.keywordAuthorT-type calcium channel blockers-
dc.subject.keywordAuthor1,4-Diazepanes-
dc.subject.keywordAuthorHeteroaromatic compounds-
dc.subject.keywordAuthorFDSS6000 assay-
dc.subject.keywordAuthorPatch-clamp assay-
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