DSpace at KISTKIST Article2011

A Regioselective Synthesis of E-Guggulsterone

Authors
Ham, Jungyeob; Chin, Jungwook; Kang, Heonjoong
Issue Date
2011-05
Publisher
MDPI AG
Citation
MOLECULES, v.16, no.5, pp.4165 - 4171
Abstract
We have successfully prepared E-guggulsterone from 16,17-epoxypregnenolone in 84% yield over two steps via a hydrazine reduction and Oppenhauer oxidation. Additionally, isomerization was induced by heat, light (h nu) and acid catalysis to convert E-guggulsterone into the corresponding Z isomer.
Keywords
COMMIPHORA-MUKUL; STEREOCHEMISTRY; KINASE; CELLS; COMMIPHORA-MUKUL; STEREOCHEMISTRY; KINASE; CELLS; guggulsterone; inflammatory bowel diseases; regioselective synthesis; oppenhauer oxidation
ISSN
1420-3049
URI
https://pubs.kist.re.kr/handle/201004/130383
DOI
10.3390/molecules16054165
Appears in Collections:
KIST Article > 2011
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