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dc.contributor.authorLee, Junsang-
dc.contributor.authorNam, Bong Soo-
dc.contributor.authorKim, Hwan-
dc.contributor.authorOh, Chang-Hyun-
dc.contributor.authorLee, So Ha-
dc.contributor.authorCho, Seung Joo-
dc.contributor.authorSim, Tae Bo-
dc.contributor.authorHah, Jung-Mi-
dc.contributor.authorKim, Dong Jin-
dc.contributor.authorTae, Jinsung-
dc.contributor.authorYoo, Kyung Ho-
dc.date.accessioned2024-01-20T18:31:20Z-
dc.date.available2024-01-20T18:31:20Z-
dc.date.created2021-09-05-
dc.date.issued2010-10-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131011-
dc.description.abstractThe synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 mu M) and good selectivity over HS27 fibroblast cell line. (C) 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectRANDOMIZED PHASE-III-
dc.subjectMETASTATIC MELANOMA-
dc.subjectMALIGNANT-MELANOMA-
dc.subjectDACARBAZINE-
dc.subjectCHEMOTHERAPY-
dc.subjectCISPLATIN-
dc.subjectINTERLEUKIN-2-
dc.subjectFOTEMUSTINE-
dc.subjectEXPERIENCE-
dc.subjectTHERAPY-
dc.titleSynthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2010.08.010-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.20, no.19, pp.5722 - 5725-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume20-
dc.citation.number19-
dc.citation.startPage5722-
dc.citation.endPage5725-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000281735600026-
dc.identifier.scopusid2-s2.0-77957592790-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusRANDOMIZED PHASE-III-
dc.subject.keywordPlusMETASTATIC MELANOMA-
dc.subject.keywordPlusMALIGNANT-MELANOMA-
dc.subject.keywordPlusDACARBAZINE-
dc.subject.keywordPlusCHEMOTHERAPY-
dc.subject.keywordPlusCISPLATIN-
dc.subject.keywordPlusINTERLEUKIN-2-
dc.subject.keywordPlusFOTEMUSTINE-
dc.subject.keywordPlusEXPERIENCE-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordAuthorAminoquinazolines-
dc.subject.keywordAuthorSynthesis-
dc.subject.keywordAuthorAntiproliferative activity-
dc.subject.keywordAuthorA375 human melanoma cell line-
dc.subject.keywordAuthorSelectivity-
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