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In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles

Authors
Koo, Heebeom; Lee, Hyejung; Lee, Sojin; Min, Kyung Hyun; Kim, Min Sang; Lee, Doo Sung; Choi, Yongseok; Kwon, Ick Chan; Kim, Kwangmeyung; Jeong, Seo Young
Issue Date
2010-08
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.46, no.31, pp.5668 - 5670
Abstract
We report protoporphyrin IX (PpIX) encapsulated pH-responsive micelles for cancer treatment. This system showed pH-responsive micellization/demicellization transition at tumoral acidic pH and enabled in vivo tumor diagnosis and therapy simultaneously.
Keywords
BLOCK-COPOLYMER MICELLES; CANCER-THERAPY; SINGLET OXYGEN; NANOPARTICLES; DELIVERY; PHOTOSENSITIZER; GENERATION; LIPOSOMES; APOPTOSIS; EFFICACY; BLOCK-COPOLYMER MICELLES; CANCER-THERAPY; SINGLET OXYGEN; NANOPARTICLES; DELIVERY; PHOTOSENSITIZER; GENERATION; LIPOSOMES; APOPTOSIS; EFFICACY
ISSN
1359-7345
URI
https://pubs.kist.re.kr/handle/201004/131235
DOI
10.1039/c0cc01413c
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KIST Article > 2010
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