DSpace at KIST: Inhibitory Effects of 3,5-O-Dicaffeoyl-epi-quinic Acid from Gymnaster koraiensis on AKR1B10

Inhibitory Effects of 3,5-O-Dicaffeoyl-epi-quinic Acid from Gymnaster koraiensis on AKR1B10

Authors: Lee, Joo Young; Song, Dae-Geun; Lee, Eun Ha; Jung, Sang Hoon; Nho, Chu Won; Cha, Kwang Hyun; Pan, Cheol-Ho

Citation: JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.52, no.6, pp.731 - 734

Abstract: AKR1B10 is a human NADPH-dependent aldo-keto reductase family 1 1310, which has been considered as a potential cancer therapeutic target. 3,5-O-Dicaffeoyl-epi-quinic acid (3,5-DCQA) was isolated from ethyl acetate fraction of Gymnaster koraiensis (Nakai) Kitam as an AKR1B10 inhibitor. 3,5-DCQA inhibited the activity of recombinant human AKR1B10 (rhAKR1B10) with its IC50 value of 1.2 mu M and its inhibition mode was uncompetitive from enzyme kinetic analysis.

Keywords: KETO REDUCTASE FAMILY-1; B10; MEMBER; KETO REDUCTASE FAMILY-1; B10; MEMBER; AKR1B10; aldose reductase-like; anticancer; 3,5-DCQA; 3,5-O-dicaffeoyl-epi-quinic acid; Gymnaster koraiensis

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