피브린 글루/알지네이트 상호 침투 구조체에 의한 지혈 및 기계적 물성 개선

Abstract

Fibrin glue (FG) has been worldwidely used as a potent surgical adhesive for microvascular blood vessel anastomoses. It needs to improve some problems in present clinical uses by allowing a quicker clotting time and higher mechanical properties. The purpose of this study aims to engineer the novel fibrin glue/alginate (ALG) interpenetrating network (FG-ALG IPN) adhesive to achieve both requirements. The alginate networks in FG shorten the clotting time and enhance the mechanical properties. However, the incorporation of ampicillin (AMP) as antibiotics does not affect both clotting time and mechanical properties. As a consequence, this novel FG-ALG IPN is expected to be used for hemostasis, tissue adhesive, suture support, wound care, sealing and filling of body defect, drug carriers, and tissue-engineered scaffolds.