DSpace at KISTKIST Article2008

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dc.contributor.authorUm, Yumi-
dc.contributor.authorCho, Sungsik-
dc.contributor.authorWoo, Ho Bum-
dc.contributor.authorKim, Yong Kee-
dc.contributor.authorKim, Hanna-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorKim, Su-Nam-
dc.contributor.authorAhn, Chan Mug-
dc.contributor.authorLee, Seokjoon-
dc.date.accessioned2024-01-20T23:31:47Z-
dc.date.available2024-01-20T23:31:47Z-
dc.date.created2021-09-03-
dc.date.issued2008-04-01-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133564-
dc.description.abstractIn order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells. (C) 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectP-GLYCOPROTEIN-
dc.subjectBIOLOGICAL EVALUATION-
dc.subjectCANCER-CELLS-
dc.subjectDERIVATIVES-
dc.subjectANTICANCER-
dc.subjectMODULATION-
dc.subjectINHIBITION-
dc.subjectTHERAPY-
dc.subjectANALOGS-
dc.subjectAGENTS-
dc.titleSynthesis of curcumin mimics with multidrug resistance reversal activities-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2008.02.012-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.16, no.7, pp.3608 - 3615-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume16-
dc.citation.number7-
dc.citation.startPage3608-
dc.citation.endPage3615-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000255245900014-
dc.identifier.scopusid2-s2.0-41649097357-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusP-GLYCOPROTEIN-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusANTICANCER-
dc.subject.keywordPlusMODULATION-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusAGENTS-
dc.subject.keywordAuthorcurcumin-
dc.subject.keywordAuthorcurcumin mimics-
dc.subject.keywordAuthormultidrug resistance-
dc.subject.keywordAuthormultidrug resistance reversal activities-
dc.subject.keywordAuthoranticancer-
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