Hesperetin의 I-131 표지 및 生體 分布 分析을 통한 歸經 연구

Other Titles
Study on the Attributive Channel Theory of Herbal Medicine by the Pharmacodynamic Research of I-131 Labelled Hesperetin
Authors
김성규함인혜부영민김호철조정혁최호영
Issue Date
2008-03
Publisher
대한본초학회
Citation
대한본초학회지, v.23, no.1, pp.117 - 125
Abstract
Objectives : This study was to verify the Attributive Channel theory of herbal medicine.Methods : [131I]iodohesperetin was synthesized, separated, and refined from hesperetin, the major component of Citrus species, followed by observing the biodistribution in an organism of C57 BL/6 mice with and without Lewis Lung Carcinoma.Results : Iodohesperetin 27.5 mg was obtained through column chromatography after a reaction with 50 mg of Hesperitin and 8 mg of NaI. The radiochemical yield of [131I]iodohesperetin synthesis was 25 % when checked with Radio TLC chromatography. [131I]iodohesperetin was most largely distributed in the stomach, lung and liver of C57BL/6 mouse. The highest %ID/g in stomach was 40 min, in lung and liver was 20 min after injection. The % ID/g of tumor tissue was comparable with that of blood.Conclusions : The fact that [131I]iodocurcumin was most largely distributed in the stomach, lung and liver was related with the Attributive Channel theory. And there was no significant finding related to tumor cells.
Keywords
Attributive Channel; I-131; Hesperetin; biodistribution; Attributive Channel; I-131; Hesperetin; biodistribution
ISSN
1229-1765
URI
https://pubs.kist.re.kr/handle/201004/133688
Appears in Collections:
KIST Article > 2008
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