Hesperetin의 I-131 표지 및 生體 分布 分析을 통한 歸經 연구
- Other Titles
- Study on the Attributive Channel Theory of Herbal Medicine by the Pharmacodynamic Research of I-131 Labelled Hesperetin
- Authors
- 김성규; 함인혜; 부영민; 김호철; 조정혁; 최호영
- Issue Date
- 2008-03
- Publisher
- 대한본초학회
- Citation
- 대한본초학회지, v.23, no.1, pp.117 - 125
- Abstract
- Objectives : This study was to verify the Attributive Channel theory of herbal medicine.Methods : [131I]iodohesperetin was synthesized, separated, and refined from hesperetin, the major component of Citrus species, followed by observing the biodistribution in an organism of C57 BL/6 mice with and without Lewis Lung Carcinoma.Results : Iodohesperetin 27.5 mg was obtained through column chromatography after a reaction with 50 mg of Hesperitin and 8 mg of NaI. The radiochemical yield of [131I]iodohesperetin synthesis was 25 % when checked with Radio TLC chromatography. [131I]iodohesperetin was most largely distributed in the stomach, lung and liver of C57BL/6 mouse. The highest %ID/g in stomach was 40 min, in lung and liver was 20 min after injection. The % ID/g of tumor tissue was comparable with that of blood.Conclusions : The fact that [131I]iodocurcumin was most largely distributed in the stomach, lung and liver was related with the Attributive Channel theory. And there was no significant finding related to tumor cells.
- Keywords
- Attributive Channel; I-131; Hesperetin; biodistribution; Attributive Channel; I-131; Hesperetin; biodistribution
- ISSN
- 1229-1765
- URI
- https://pubs.kist.re.kr/handle/201004/133688
- Appears in Collections:
- KIST Article > 2008
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