DSpace at KISTKIST Article2007

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dc.contributor.authorOlshevskaya, Valentina A.-
dc.contributor.authorSavchenko, Arina N.-
dc.contributor.authorGorshkov, Alexander Yu.-
dc.contributor.authorLuzgina, Valentina N.-
dc.contributor.authorTatarskii, Victor V., Jr.-
dc.contributor.authorKononova, Elena G.-
dc.contributor.authorCheong, Chan Seong-
dc.contributor.authorKalinin, Valery N.-
dc.contributor.authorShtil, Alexander A.-
dc.date.accessioned2024-01-21T00:04:46Z-
dc.date.available2024-01-21T00:04:46Z-
dc.date.created2021-08-31-
dc.date.issued2007-12-
dc.identifier.issn0010-0765-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133964-
dc.description.abstractWe report the synthesis of novel conjugates of protohemin IX with neutral and anionic boron polyhedra and L-amino acids. The amino acids are linked to the porphyrin macrocycle via the amide or ester bond. The serine containing boronated protohemin was the most cytotoxic for K562 human leukemia cell line. This compound interacted with double-stranded DNA in vitro and caused apoptosis of tumor cells including those that are resistant to several chemotherapeutic drugs.-
dc.languageEnglish-
dc.publisherINST ORGANIC CHEM AND BIOCHEM-
dc.subjectPORPHYRINS-
dc.titleBoronated conjugates of protohemin IX with L-amino acids: Synthesis and antitumor activity-
dc.typeArticle-
dc.identifier.doi10.1135/cccc20071707-
dc.description.journalClass1-
dc.identifier.bibliographicCitationCOLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, v.72, no.12, pp.1707 - 1716-
dc.citation.titleCOLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS-
dc.citation.volume72-
dc.citation.number12-
dc.citation.startPage1707-
dc.citation.endPage1716-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000252670100009-
dc.identifier.scopusid2-s2.0-40749107315-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPORPHYRINS-
dc.subject.keywordAuthorprotohemin IX-
dc.subject.keywordAuthorL-amino acids-
dc.subject.keywordAuthorcytotoxicity-
dc.subject.keywordAuthorDNA fragmentation-
dc.subject.keywordAuthorantitumor drugs-
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KIST Article > 2007
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