Novel 1 beta-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in vitro antibacterial activity

Abstract

The synthesis of a new series of 1 beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1, 1-dioxide moiety showed the most potent antibacterial activity. (c) 2007 Elsevier Masson SAS. All rights reserved.