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dc.contributor.authorByeon, Seong Rim-
dc.contributor.authorLee, Ji Hoon-
dc.contributor.authorSohn, Ji-Hoon-
dc.contributor.authorKim, Dong Chan-
dc.contributor.authorShin, Kye Jung-
dc.contributor.authorYoo, Kyung Ho-
dc.contributor.authorMook-Jung, Inhee-
dc.contributor.authorLee, Won Koo-
dc.contributor.authorKim, Dong Jin-
dc.date.accessioned2024-01-21T01:06:40Z-
dc.date.available2024-01-21T01:06:40Z-
dc.date.created2021-08-31-
dc.date.issued2007-03-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134549-
dc.description.abstractNew bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by A beta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for A beta fibril formation at IC50 of 0.1-2.7 mu M which is comparable to curcumin (IC50 of 0.8 mu M). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 mu M. In particular, 1-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectAMYLOID HYPOTHESIS-
dc.subjectALPHA-SYNUCLEIN-
dc.subjectPLAQUES-
dc.subjectMEDICINE-
dc.subjectCURCUMIN-
dc.titleBis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for A beta fibril formation-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2006.10.090-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.5, pp.1466 - 1470-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume17-
dc.citation.number5-
dc.citation.startPage1466-
dc.citation.endPage1470-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000244943300065-
dc.identifier.scopusid2-s2.0-33846931387-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusAMYLOID HYPOTHESIS-
dc.subject.keywordPlusALPHA-SYNUCLEIN-
dc.subject.keywordPlusPLAQUES-
dc.subject.keywordPlusMEDICINE-
dc.subject.keywordPlusCURCUMIN-
dc.subject.keywordAuthorA beta fibril formation inhibitor-
dc.subject.keywordAuthorAlzheimer disease-
dc.subject.keywordAuthorbis-styrylpyridine-
dc.subject.keywordAuthorbis-styrylbenzene-
dc.subject.keywordAuthoramyloid beta-
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