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dc.contributor.authorChoo, Hyunah-
dc.contributor.authorBeadle, James R.-
dc.contributor.authorChong, Youhoon-
dc.contributor.authorTrahan, Julissa-
dc.contributor.authorHostetler, Karl Y.-
dc.date.accessioned2024-01-21T01:32:32Z-
dc.date.available2024-01-21T01:32:32Z-
dc.date.created2021-08-31-
dc.date.issued2007-02-15-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134647-
dc.description.abstractA new class of acyclic nucleoside phosphonates, the 5-phosphono-pent-2-en-1-yl nucleosides and their hexadecyloxypropyl esters, were synthesized from butyn-1-ol. Only the hexadecyloxypropyl esters showed antiviral activity against herpes simplex virus type 1. in vitro. Hexaclecyloxypropyl 1-(5-phosphono-pent-2-en-1-yl)-thymine was the most active and selective compound among the synthesized nucleotides with an EC50 value of 0.90 mu M. (c) 2006 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectHERPES-SIMPLEX-VIRUS-
dc.subjectETHER LIPID ESTERS-
dc.subjectORAL TREATMENT-
dc.subjectCIDOFOVIR-
dc.subjectCYTOMEGALOVIRUS-
dc.subjectALKOXYALKYL-
dc.subjectINFECTIONS-
dc.subjectDRUGS-
dc.titleSynthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2006.11.038-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.15, no.4, pp.1771 - 1779-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume15-
dc.citation.number4-
dc.citation.startPage1771-
dc.citation.endPage1779-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000243983800020-
dc.identifier.scopusid2-s2.0-33847783139-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusHERPES-SIMPLEX-VIRUS-
dc.subject.keywordPlusETHER LIPID ESTERS-
dc.subject.keywordPlusORAL TREATMENT-
dc.subject.keywordPlusCIDOFOVIR-
dc.subject.keywordPlusCYTOMEGALOVIRUS-
dc.subject.keywordPlusALKOXYALKYL-
dc.subject.keywordPlusINFECTIONS-
dc.subject.keywordPlusDRUGS-
dc.subject.keywordAuthorantivirals-
dc.subject.keywordAuthornucleosides-
dc.subject.keywordAuthornucleoside phosphonates-
dc.subject.keywordAuthorprodrugs-
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