글루코사민의 질소친핵성을 이용한 알파-우레아글루코사민의 합성과 벼 잎집무늬마름병균에 대한 방제 활성

Abstract

Through this study, we synthesized derivatives of 2-phenylureido-α-D-glucopyranose which are expected of biological activation, and we confirmed their antibacterial activities. Also, we produced α-glucosamine and, by utilizing its nitrogen nucleophilic, then made phenylureido-α-D-glucopyranose which responds and corresponds to 13 derivatives of isocyanate. We verified degree of purity and yield of generated 2-phenylureido-α-D-glucopyranose, 1H NMR, melting point and optical rotation. As for 1H NMR spectrum, DMSO-d6 solvent is of higher sensitivity than CDCl3 and shows more stable chemical transfer, so has advantage when grasping chemical attributes. 1-H shows coupling constant(J) value of 3.4-3.6 Hz around 6.0 ppm as doublet, and this is α-chemical sign appearing in the lowest range out of 6 protons of pyranose ring. As a result of confirming control activation of rice sheath blight relative to 13 sorts of newly produced compounds in in vivo, it shows the feeble activation but it was verified that there’s sufficient evidence for antibacterial activation of glucosamine derivatives.