Optical separation of racemic ketoprofen by chiral high-performance liquid chromatography
- Optical separation of racemic ketoprofen by chiral high-performance liquid chromatography
- 김소영; 이중기; 서성섭; 최민호; 박태진; 박달근
- ketoprofen; Enantiomer; Separation; HPLC; Chiral Stationary Phase
- Issue Date
- Journal of the Korean Institute of Chemical Engineers
- VOL 39, NO 6, 698-704
- Ketoprofen, a phenylpropionic acid derivative, is a non-steroidal anti-inflammatory drug(NSAID) that has analgesic,
anti-inflammatory and antipyretic properties. Pharmacological activity has been attributed mainly to the S-(+)-enantiomer,
while the R-(-)-enantiomer is either inactive or has side effect. The optical separation of Ketoprofen enantiomers was
carried out by various chiral HPLC(chiral high-performance liquid chromatography) columns and most compatible separation
conditions of Ketoprofen enantiomers were investigated. The resolution and enantio selectivity of Ketoprofen were found to be
strongly influenced by the employed chiral stationary phases(CSPs) and composition of eluents. The employed chiral stationary
phases(CSPs) in this study were b-CD BR？ and Kromasil？. The optimum composition of eluent was obtained differently for
stationary material phase. The effects of process variables such as flow rate, injection volume, and concentration of eluent on
Ketoprofen enantiomers separation were investigated using Kromasil？ columns. The resolution decreased with the increase of
injection volume, however, the effect became insignificant at higher flow rate.
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