Optical separation of racemic ketoprofen by chiral high-performance liquid chromatography

Title
Optical separation of racemic ketoprofen by chiral high-performance liquid chromatography
Authors
김소영이중기서성섭최민호박태진박달근
Keywords
ketoprofen; Enantiomer; Separation; HPLC; Chiral Stationary Phase
Issue Date
2001-12
Publisher
Journal of the Korean Institute of Chemical Engineers
Citation
VOL 39, NO 6, 698-704
Abstract
Ketoprofen, a phenylpropionic acid derivative, is a non-steroidal anti-inflammatory drug(NSAID) that has analgesic, anti-inflammatory and antipyretic properties. Pharmacological activity has been attributed mainly to the S-(+)-enantiomer, while the R-(-)-enantiomer is either inactive or has side effect. The optical separation of Ketoprofen enantiomers was carried out by various chiral HPLC(chiral high-performance liquid chromatography) columns and most compatible separation conditions of Ketoprofen enantiomers were investigated. The resolution and enantio selectivity of Ketoprofen were found to be strongly influenced by the employed chiral stationary phases(CSPs) and composition of eluents. The employed chiral stationary phases(CSPs) in this study were b-CD BR? and Kromasil?. The optimum composition of eluent was obtained differently for stationary material phase. The effects of process variables such as flow rate, injection volume, and concentration of eluent on Ketoprofen enantiomers separation were investigated using Kromasil? columns. The resolution decreased with the increase of injection volume, however, the effect became insignificant at higher flow rate.
URI
http://pubs.kist.re.kr/handle/201004/13758
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