Lack of association between the S20G missense mutation of amylin gene and essential hypertension in korean population.
- Lack of association between the S20G missense mutation of amylin gene and essential hypertension in korean population.
- Byung Yong Kang; Joon Seol Bae; Jae Hyoun Kim; Ae Son Om; 류재천; Hyun Seon Eo; Jae Hyun Shin; Jung Hee Shin; Chung Choo Lee; Ki Tae Kim
- amylin; Essential Hypertension and Genotype
- Issue Date
- Environmental Mutagens & Carcinogens (한국환경성돌연변이발암원학회지)
- VOL 21, NO 2, 72-76
- Essential hypertension is a heterogeneously multifactorial disease in which blood pressure is
harmfully high without overt cause. Both genetic and environmental factors have been implicated in its
etiology. In view of the regulatory role of this peptide in the carbohydrate metabolism and renin-angiotensin
system, amylin gene has been proposed to a candidate gene for essential hypertension. Therefore, we scanned
the amylin gene for mutations in 133 Korean normotensives and 61 essential hypertensives by single-strand
conformational polymorphism, and found a single heterozygous S20G missense mutation. However, no
significant difference was observed between normotensives and essential hypertensives in the distribution of
allele and genotype frequencies of this mutation at the amylin gene (P > 0.05). This finding suggests that S20G
missense mutation of the amylin gene are unlikely to contribute to the etiology of essential hypertension in the
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