Lack of association between the S20G missense mutation of amylin gene and essential hypertension in korean population.

Title
Lack of association between the S20G missense mutation of amylin gene and essential hypertension in korean population.
Authors
Byung Yong KangJoon Seol BaeJae Hyoun KimAe Son Om류재천Hyun Seon EoJae Hyun ShinJung Hee ShinChung Choo LeeKi Tae Kim
Keywords
amylin; Essential Hypertension and Genotype
Issue Date
2001-12
Publisher
Environmental Mutagens & Carcinogens (한국환경성돌연변이발암원학회지)
Citation
VOL 21, NO 2, 72-76
Abstract
Essential hypertension is a heterogeneously multifactorial disease in which blood pressure is harmfully high without overt cause. Both genetic and environmental factors have been implicated in its etiology. In view of the regulatory role of this peptide in the carbohydrate metabolism and renin-angiotensin system, amylin gene has been proposed to a candidate gene for essential hypertension. Therefore, we scanned the amylin gene for mutations in 133 Korean normotensives and 61 essential hypertensives by single-strand conformational polymorphism, and found a single heterozygous S20G missense mutation. However, no significant difference was observed between normotensives and essential hypertensives in the distribution of allele and genotype frequencies of this mutation at the amylin gene (P > 0.05). This finding suggests that S20G missense mutation of the amylin gene are unlikely to contribute to the etiology of essential hypertension in the Korean population.
URI
http://pubs.kist.re.kr/handle/201004/13765
ISSN
1225-6307
Appears in Collections:
KIST Publication > Article
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