Synthesis and binding affinities of 2 β -(3-iodoallyloxycarbonyl)-3 β -(4-substituted-aryl)tropane analogues as ligands for the

Title
Synthesis and binding affinities of 2 β -(3-iodoallyloxycarbonyl)-3 β -(4-substituted-aryl)tropane analogues as ligands for the
Authors
정규현임충환이동률진창배지대윤
Keywords
tropane analogues
Issue Date
2001-12
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 11, NO 23, 3077-3080
Abstract
Abstract—Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3b-aryl-2b-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [3H]2b-carbomethoxy- 3b-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes. # 2001 Elsevier Science Ltd. All rights reserved.
URI
http://pubs.kist.re.kr/handle/201004/13784
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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