DSpace at KIST: Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

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DSpace at KISTKIST Article 2003

Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Authors: Jeong, LS; Moon, HR; Park, JC; Shin, DH; Choi, WJ; Lee, KM; Kim, HO; Chun, MW; Kim, HD; Kim, JH

Issue Date: 2003-10

Publisher: MARCEL DEKKER INC

Citation: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.22, no.5-8, pp.589 - 592

Abstract: Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

Keywords: halo-neplanocin A; S-Adenosylhomocysteine hydrolase; mechanism-based inhibitor

ISSN: 1525-7770

URI: https://pubs.kist.re.kr/handle/201004/138218

DOI: 10.1081/NCN-120021961

Appears in Collections:: KIST Article > 2003

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