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High transfection efficiency of poly(4-vinylimidazole) as a new gene carrier

Authors
Ihm, JE; Han, KO; Han, IK; Ahn, KD; Han, DK; Cho, CS
Issue Date
2003-07
Publisher
AMER CHEMICAL SOC
Citation
BIOCONJUGATE CHEMISTRY, v.14, no.4, pp.707 - 708
Abstract
Poly(4-vinylimidazole) (P4V) was obtained by free radical polymerization of 4-vinylimidazole (4V) prepared by decarboxylation of urocanic acid. P4V formed a complex with DNA that exhibited higher transfection effiency on Hela cells than polyethylenimine (PEI), through the proton sponge mechanism of the imidazole groups in the side chain of the P4V, and low cell toxicity.
Keywords
IN-VIVO; THERAPY; COMPLEXES; POLYMERS; IN-VIVO; THERAPY; COMPLEXES; POLYMERS; gene carrier; poly(4-vinylimidazole); transfection; gene theraphy
ISSN
1043-1802
URI
https://pubs.kist.re.kr/handle/201004/138426
DOI
10.1021/bc025611q
Appears in Collections:
KIST Article > 2003
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