C-2-symmetric bisphosphine ligands derived from 1,1 '-binaphthyldiamines and diphenylphosphinobenzoic acid for palladium catalyzed desymmetrizations

Abstract

A series of novel C-2-symmetric bisphosphine ligands derived from DPPBA and C-2-symmetric 1,1'-binaphthyldiamines has been synthesized. In palladium catalyzed desymmetrization of meso cyclic carbamates, the enantioselectivity and the stereochemistry of the major enantiomers are largely affected by the substitution position of DPPBA moiety on the 1,1'-binaphthyl chiral scaffold. (C) 2000 Elsevier Science Ltd. All rights reserved.