Synthesis of pyrrolidine or piperidine ring-fused azepino[5,4,3-cd]indole derivatives

Abstract

The synthesis of pyrrolidine or piperidine ring-fused 2-phenylazepino[5,4,3-cd]indole derivatives (2) has been accomplished through the N-acyliminium ion cyclization of hydroxy- or alkoxylactams (5) derived from cyclic anhydrides or chiral hydroxy acids. (C) 1999 Elsevier Science Ltd. All rights reserved.