Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives

Abstract

The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R' position contributes to the analgesic activity.