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dc.contributor.authorKim, K.-R.-
dc.contributor.authorShin, Y.-J.-
dc.contributor.authorShim, W.-H.-
dc.contributor.authorMyung, S.-W.-
dc.date.accessioned2024-01-21T22:11:18Z-
dc.date.available2024-01-21T22:11:18Z-
dc.date.created2021-09-02-
dc.date.issued1994-01-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/145917-
dc.description.abstractThe solid-phase extraction (SPE) with subsequent tert.-butyldimethylsilyl (TBDMS) derivatization was investigated for the rapid profiling and screening of various carboxylated non-steroidal antiinflammatory drugs (NSAIDs) simultaneously in biological fluid samples. Compared to the conventional SPE in adsorption mode using Chromosorb 102, Chromosorb 107, Carbopak B and Thermosorb, the SPE in partition mode using Chromosorb P as the adsorbent, and ethyl acetate/methylene chloride as the eluting solvents provided highest overall recoveries of the NSAIDs from aqueous solutions with good precision. The solid-phase extracted NSAIDs were silylated with N-methyl-N-(tert.-butyldimethylsilyl)trifluoroacetamide to TBDMS derivatives and directly analyzed by capillary gas chromatography and gas chromatography-mass spectrometry. The usefulness of the present method was examined for the profiling and screening of saliva, serum and urine samples for various NSAIDs simultaneously. ？ 1994, The Pharmaceutical Society of Korea. All rights reserved.-
dc.languageEnglish-
dc.subjectalclofenac-
dc.subjectdiclofenac-
dc.subjectdiflunisal-
dc.subjectfenclofenac-
dc.subjectfenoprofen-
dc.subjectflufenamic acid-
dc.subjectflunixin-
dc.subjectflurbiprofen-
dc.subjectibuprofen-
dc.subjectindometacin-
dc.subjectindoprofen-
dc.subjectketoprofen-
dc.subjectlonazolac-
dc.subjectmefenamic acid-
dc.subjectnaproxen-
dc.subjectniflumic acid-
dc.subjectnonsteroid antiinflammatory agent-
dc.subjectpirprofen-
dc.subjectsuprofen-
dc.subjecttolfenamic acid-
dc.subjectzomepirac-
dc.subjectarticle-
dc.subjectderivatization-
dc.subjectdrug blood level-
dc.subjectdrug determination-
dc.subjectdrug saliva level-
dc.subjectdrug urine level-
dc.subjectgas chromatography-
dc.subjecthuman-
dc.subjectmass spectrometry-
dc.subjectmethodology-
dc.subjectnonhuman-
dc.titleRapid gas chromatographic profiling and screening of acidic non-steroidal antiinflammatory drugs in biological samples-
dc.typeArticle-
dc.identifier.doi10.1007/BF02974255-
dc.description.journalClass1-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, v.17, no.3, pp.175 - 181-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.volume17-
dc.citation.number3-
dc.citation.startPage175-
dc.citation.endPage181-
dc.description.journalRegisteredClassscopus-
dc.identifier.scopusid2-s2.0-0028070692-
dc.type.docTypeArticle-
dc.subject.keywordPlusalclofenac-
dc.subject.keywordPlusdiclofenac-
dc.subject.keywordPlusdiflunisal-
dc.subject.keywordPlusfenclofenac-
dc.subject.keywordPlusfenoprofen-
dc.subject.keywordPlusflufenamic acid-
dc.subject.keywordPlusflunixin-
dc.subject.keywordPlusflurbiprofen-
dc.subject.keywordPlusibuprofen-
dc.subject.keywordPlusindometacin-
dc.subject.keywordPlusindoprofen-
dc.subject.keywordPlusketoprofen-
dc.subject.keywordPluslonazolac-
dc.subject.keywordPlusmefenamic acid-
dc.subject.keywordPlusnaproxen-
dc.subject.keywordPlusniflumic acid-
dc.subject.keywordPlusnonsteroid antiinflammatory agent-
dc.subject.keywordPluspirprofen-
dc.subject.keywordPlussuprofen-
dc.subject.keywordPlustolfenamic acid-
dc.subject.keywordPluszomepirac-
dc.subject.keywordPlusarticle-
dc.subject.keywordPlusderivatization-
dc.subject.keywordPlusdrug blood level-
dc.subject.keywordPlusdrug determination-
dc.subject.keywordPlusdrug saliva level-
dc.subject.keywordPlusdrug urine level-
dc.subject.keywordPlusgas chromatography-
dc.subject.keywordPlushuman-
dc.subject.keywordPlusmass spectrometry-
dc.subject.keywordPlusmethodology-
dc.subject.keywordPlusnonhuman-
dc.subject.keywordAuthorBiological sample-
dc.subject.keywordAuthorChromosorb P-
dc.subject.keywordAuthorNSAIDs-
dc.subject.keywordAuthorScreening-
dc.subject.keywordAuthorSolid-phase extraction-
dc.subject.keywordAuthorTBDMS derivatization-
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