Enzymatic kinetic resolution of ketorolac

Title
Enzymatic kinetic resolution of ketorolac
Authors
김영희정찬성이소하김관수
Keywords
kinetic resolution
Issue Date
2001-09
Publisher
Tetrahedron, asymmetry
Citation
VOL 12, NO 3, 1865-1869
Abstract
Ketorolac 1 was resolved into each enantiomer by interesterification using lipase B from Candida antarctica. The acid reacted with various alcohols and the ester and acid were resolved up to >99% e.e. when reacted with octanol, which was the best result. To increase reactivity and enantioselectivity, the experimental conditions were adjusted by varying temperature, solvent, alcohols and reaction time. © 2001 Published by Elsevier Science Ltd.
URI
http://pubs.kist.re.kr/handle/201004/16221
ISSN
0957-4166
Appears in Collections:
KIST Publication > Article
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