Enzymatic kinetic resolution of ketorolac
- Enzymatic kinetic resolution of ketorolac
- 김영희; 정찬성; 이소하; 김관수
- kinetic resolution
- Issue Date
- Tetrahedron, asymmetry
- VOL 12, NO 3, 1865-1869
- Ketorolac 1 was resolved into each enantiomer by interesterification using lipase B from Candida antarctica. The acid
reacted with various alcohols and the ester and acid were resolved up to >99% e.e. when reacted with octanol, which was the best
result. To increase reactivity and enantioselectivity, the experimental conditions were adjusted by varying temperature, solvent,
alcohols and reaction time. © 2001 Published by Elsevier Science Ltd.
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