Prenatal treatment effects of oriental herbal medicine Kamijadowhan on developmental and reproductive toxicity in rats
- Prenatal treatment effects of oriental herbal medicine Kamijadowhan on developmental and reproductive toxicity in rats
- Young-Jin Park; Jung-Ran Kim; 류재천; Bum-Sang Shim; Seung-Hoon Choi; 권오승
- Kamijadowhan; Oriental herbal medicine; Developmental toxicity; Reproductive toxicity; Pregnant rats
- Issue Date
- Environmental Mutagens & Carcinogens (한국환경성돌연변이발암원학회지)
- VOL 21, NO 2, 77-81
- Kamijadowhan (KMD), an oriental herbal medicine used for anti-angiogenic effect, was extracted
with 80% ethanol from mixture of source materials and lyophilized. KMD was orally administered to plugpositive
pregnant rats from gestational days 12 to 20, dividing into three groups including vehicle-treated
control, 0.5 g/kg or 3 g/kg KMD-treated groups. Dam weight during gestation and post-gestation, weight of preand
post-weaning offsprings in male and female, and reproductive and developmental endpoints including
incisor eruption, eye opening and testes descent were measured. No significant alterations in development of
physical landmarks in offspring, maternal weight gain during gestation and post-gestation, and offspring weight
were observed in KMD-treated group. The measurement of organ weight at post-gestational days 21 was not
changed in dams. In 0.5 g/kg KMD-treated rats, kidney weights in male and female offsprings were significantly
increased, and the body weight in male offspring was also increased. Liver and brain weights were not changed.
Taken together, these data suggest that KMD may not significantly cross the placenta and produce no
reproductive and developmental toxicity at maternally non-toxic dosages.
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