Prenatal treatment effects of oriental herbal medicine Kamijadowhan on developmental and reproductive toxicity in rats

Title
Prenatal treatment effects of oriental herbal medicine Kamijadowhan on developmental and reproductive toxicity in rats
Authors
Young-Jin ParkJung-Ran Kim류재천Bum-Sang ShimSeung-Hoon Choi권오승
Keywords
Kamijadowhan; Oriental herbal medicine; Developmental toxicity; Reproductive toxicity; Pregnant rats
Issue Date
2001-12
Publisher
Environmental Mutagens & Carcinogens (한국환경성돌연변이발암원학회지)
Citation
VOL 21, NO 2, 77-81
Abstract
Kamijadowhan (KMD), an oriental herbal medicine used for anti-angiogenic effect, was extracted with 80% ethanol from mixture of source materials and lyophilized. KMD was orally administered to plugpositive pregnant rats from gestational days 12 to 20, dividing into three groups including vehicle-treated control, 0.5 g/kg or 3 g/kg KMD-treated groups. Dam weight during gestation and post-gestation, weight of preand post-weaning offsprings in male and female, and reproductive and developmental endpoints including incisor eruption, eye opening and testes descent were measured. No significant alterations in development of physical landmarks in offspring, maternal weight gain during gestation and post-gestation, and offspring weight were observed in KMD-treated group. The measurement of organ weight at post-gestational days 21 was not changed in dams. In 0.5 g/kg KMD-treated rats, kidney weights in male and female offsprings were significantly increased, and the body weight in male offspring was also increased. Liver and brain weights were not changed. Taken together, these data suggest that KMD may not significantly cross the placenta and produce no reproductive and developmental toxicity at maternally non-toxic dosages.
URI
http://pubs.kist.re.kr/handle/201004/16705
ISSN
1225-6307
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KIST Publication > Article
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