Synthesis and in vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands.

Title
Synthesis and in vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands.
Authors
차주환조용서배애님고훈영정대영공재양이은최경일
Keywords
1-azabicyclic compounds
Issue Date
2001-11
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 11, NO 21, 2855-2857
Abstract
Two series of compounds, 2 and 3, were synthesized and their binding affinities were evaluated for the human recombinant muscarinic M1 receptor subtype expressed in CHO cells. Comparing their binding affinities for the NMS binding sites and the Oxo-M binding sites, they were assumed as agonists. In particular, compound 2e was a good ligand for the agonist binding sites with an IC50 of 23 nM, which represents over 1585 times stronger binding than for the antagonist binding sites. # 2001 Elsevier Science Ltd. All rights reserved.
URI
http://pubs.kist.re.kr/handle/201004/16743
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE