6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors

Title
6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors
Authors
이용섭이용실이재열김순남이종교박호군
Keywords
HIV; non-peptidic; inhibitor; pyrone; 1,3-dioxin-4-one; sulfonamide
Issue Date
2000-12
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 10, NO 23, 2625-2627
Abstract
HIV protease inhibitors containing 6-hydroxy-1,3-dioxin-4-one ring system as a new scaffold have been prepared. Among them, compound 4d showed potent HIV protease inhibitory activity (IC50 = 0.01 microM) and antiviral activity in cell culture (EC50 = 0.96 microM, SI = 65.69).
URI
http://pubs.kist.re.kr/handle/201004/17387
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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