Synthesis and antibacterial activities of new carbapenems having a proline reverse amide moiety at the C-2 position

Title
Synthesis and antibacterial activities of new carbapenems having a proline reverse amide moiety at the C-2 position
Authors
황순호신계정강용구김동진김동찬유경호박상우이기정
Keywords
1 - β - Methylcarbapenems; proline reverse amide moiety; antibacterial activities
Issue Date
1998-04
Publisher
Archiv der Pharmazie
Citation
VOL 331, NO 4, 139-142
Abstract
The synthesis of new 1β-methylcarbapenems (1a–l) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Mueller-Hinton agar dilution method and compared with meropenem as control. Aliphatic amides (1a–h) are found to show greater antibacterial activity than aromatic amides (1i–l). Moreover, C-2 free amino compound (1m) reveals greater activity than any other amide compounds (1a–l).
URI
http://pubs.kist.re.kr/handle/201004/19190
ISSN
0365-6233
Appears in Collections:
KIST Publication > Article
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