Synthesis and biological properties of new 1 β -methylcarbapenems

Title
Synthesis and biological properties of new 1 β -methylcarbapenems
Authors
신계정유경호김동진박상우고봉석이상주허재두박승용
Keywords
Antibiotics; Antibacterials; Substituent effects
Issue Date
1998-07
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 8, 1607-1612
Abstract
The synthesis and biological activity of the novel series of 1β-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.
URI
http://pubs.kist.re.kr/handle/201004/19191
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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