Serum polyamines in pre- and post-operative patients with breast cancer corrected by menopausal status

Title
Serum polyamines in pre- and post-operative patients with breast cancer corrected by menopausal status
Authors
변정아최만호문명희공구정봉철
Keywords
serum polyamine; pre-operative; breast cancer; menopausal status; menopause; liquid chromatography-mass spectrometry; *2008년도개인평가에반영되었음
Issue Date
2009-01
Publisher
Cancer letters
Citation
VOL 273, 300-304
Abstract
Polyamines are essential for cell growth and differentiation of cells and its increased production is observed in many cancers. Due to one of key enzymes in polyamine synthesis ornithine decarboxylase is stimulated by estrogens in breast cancer cells, the polyamine levels in serum samples obtained from patients with breast cancer (BCa; pre-menopause: 45.6 ± 0.8 years old, n = 58; post-menopause: 55.2 ± 1.1 years old; n = 11), who were also classified as pre- and post-surgery, and from normal controls (pre-menopause: ages 43.6 ± 0.9 years, n = 45, post-menopause: ages 55.2 ± 1.0 years, n = 18) were determined by liquid chromatography&#8211;mass spectrometry. In pre-menopausal patients, the concentrations of 1,3-diaminopropane, N-acetyl putrescine (N-actPut), N-acetyl spermidine and spermidine (Sp) were higher (p < 0.05) in pre-surgery breast cancer patients than in normal controls, with N-actPut (p < 0.0005) and Sp (p < 0.005) levels markedly increased. All polyamine levels were slightly decreased post-surgery, and were comparable to levels in normal subjects. Based on menopausal-dependent data, the results imply that serum polyamines levels may correlate with estrogen levels in association with estrogen-induced cell growth and ornithine decarboxylase activity.
URI
http://pubs.kist.re.kr/handle/201004/33192
ISSN
0304-3835
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KIST Publication > Article
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