Deletion of N-type Ca2+ channel Cav2.2 results in hyperaggressive behaviors in mice
- Deletion of N-type Ca2+ channel Cav2.2 results in hyperaggressive behaviors in mice
- 김찬기; 전대종; 김영훈; 이창준; 김현; 신희섭
- Issue Date
- The Journal of biological chemistry
- VOL 284, NO 5, 2738-2745
- Voltage-dependent N-type Ca2 channels play important
roles in the regulation of diverse neuronal functions in the brain,
but little is known about its role in social aggressive behaviors.
Mice lacking the 1B subunit (Cav2.2) of N-type Ca2 channels
showed markedly enhanced aggressive behaviors to an intruder
mouse in the resident-intruder test. The dorsal raphe nucleus
(DRN), which contains serotonin neurons, is known to be
involved in aggression in animals. We thus examined the DRN
neurons in the Cav2.2-deficient (Cav2.2 / ) mice. Microinjection
of -conotoxin GVIA, an N-type Ca2 channel-specific
blocker, into the DRN of wild type mice resulted in escalated
aggression, mimicking the phenotypes of Cav2.2 / . Electrophysiological
analysis showed increased firing activity of serotonin
neurons with a reduced inhibitory neurotransmission in
the Cav2.2 / DRN. Cav2.2 / mice showed an elevated level of
arginine vasopressin, an aggression-related hormone, in the cerebrospinal
fluid. In addition, Cav2.2 / mice showed an increase
of serotonin in the hypothalamus. These results suggest
that N-type Ca2 channels at the DRN have a key role in the
control of aggression.
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